https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Induction of caspase-mediated apoptosis in HepG2 liver carcinoma cells using mutagen-antioxidant conjugated self-assembled novel carbazole nanoparticles and in silico modeling studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45243 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH4. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:50 AEDT ]]> Induction of caspase-mediated apoptosis in HepG2 liver carcinoma cells using mutagen-antioxidant conjugated self-assembled novel carbazole nanoparticles and in silico modeling studies https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45239 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH4. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:20 AEDT ]]> Promotion effects of pressure on polycyclic aromatic hydrocarbons and h₂ formation during flash pyrolysis of palm kernel shell https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46367 Wed 16 Nov 2022 08:58:48 AEDT ]]> In situ synthesis of Pt/TiO₂ nanosheets on flexible Ti mesh for efficient and cyclic phenol removal https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48323 2 nanostructures that feature a two-dimensional (2D) morphology have attracted extensive attention in environment processing and energy conversion fields owing to their peculiarly large surface area and superior transfer efficiency of photogenerated carriers. In this work, we proposed a hybrid approach including a plasma electrolyte oxidation (PEO) and ion exchange strategy to in situ synthesize TiO2 nanosheets on a flexible Ti mesh substrate, in which the layered Na2Ti2O5 nanosheets were fabricated as a template. The TiO2 nanosheets are crystalline anatase phase and exhibit excellent photocatalytic activity and stability in removing phenol. With the modification of the Pt cocatalyst, the phenol degradation performance has been significantly enhanced. More importantly, the in situ grown TiO2 nanosheets on the flexible Ti mesh provide strong substrate adhesion that enables superior photocatalytic stability for cyclic degradation of phenol. It can be expected that the synthetic strategy proposed in this work can pave a solid way toward the in situ growth of various TiO2-based composite nanophotocatalysts with sufficient active sites and excellent photocatalytic properties, and thus, it will open up more opportunities for environment processing and energy conversion.]]> Tue 14 Mar 2023 16:26:44 AEDT ]]> An experimental investigation of the catalytic activity of natural calcium-rich minerals and a novel dual-supported CaO-Ca12Al14O33/Al2O3 Catalyst for Biotar Steam Reforming https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47208 Mon 29 Jan 2024 17:45:48 AEDT ]]>